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Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelination

2020-01-21

Abstract excerpt

Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) leading to failed remyelination and axonal atrophy. By network-based transcriptomics, we identified sulfatase 2 (Sulf2) mRNA in activated human primary OPCs. Sulf2, an extracellular endosulfatase, modulates the signaling microenvironment b...

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Literature Corpus work
5a987748-98e2-5e1e-b0a0-10c33eb13b50
DOI
10.1101/2020.01.21.906073
Open publication

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Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelinationDOI 10.1101/2020.01.21.906073
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