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Article

The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination.

Journal of neuroinflammation - 23 Jul 2020

Pu Annie, Mishra Manoj K, Dong Yifei, Ghorbanigazar Samira, Stephenson Erin L, Rawji Khalil S, Silva Claudia, Kitagawa Hiroshi, Sawcer Stephen, Yong V Wee

Abstract excerpt

BACKGROUND: Chondroitin sulfate proteoglycans (CSPGs) are potent inhibitors of axonal regrowth and remyelination. More recently, they have also been highlighted as a modulator of macrophage infiltration into the central nervous system in experimental autoimmune encephalomyelitis, an inflammatory model of multiple sclerosis. METHODS: We interrogated results from single nucleotide polymorphisms (SNPs) lying in or...

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Source

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Identifiers

PMID: 32703234
DOI: 10.1186/s12974-020-01895-1
PMCID: PMC7379813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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