Article

Extrinsic cues unlock cross-germ layer differentiation potential of CNS stem cells during regeneration

2025-11-26

Abstract excerpt

<h4>ABSTRACT</h4> During CNS regeneration, neuroepithelial-derived oligodendrocyte progenitor cells (OPCs) can cross germ-layer boundaries to generate neural-crest-derived Schwann cells (SCs). However, the underlying mechanism and disease relevance of this unique phenomenon of cellular plasticity is unclear. Here, we combine single cell genomics in rodent models of CNS injury and samples from multiple sclerosis p...

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Literature Corpus work: 0d0a2164-205c-5fc2-95ba-bb2b93ac986d
DOI: 10.1101/2025.11.24.690179

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