Article

Heparan sulfate Sulfatases are essential for patterning of human stem cell-derived midbrain dopaminergic neurons

2025-08-11

Abstract excerpt

<title>Abstract</title> <p>Midbrain dopaminergic neurons (mDA) are selectively lost in Parkinson’s disease (PD), driving sustained efforts to generate bona fide mDA neurons from human-induced pluripotent stem cells (iPSCs) for replacement therapy. While morphogen gradients and transcription factors have been extensively studied, extracellular regulators remain largely overlooked. Here, we identify the heparan sul...

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Literature Corpus work: 73f4b4b6-84e5-550c-a77d-d7ef4a854e83
DOI: 10.21203/rs.3.rs-7190215/v1

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