Back to search

Article

The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling

2020-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Promoting oligodendrocyte differentiation represents a promising option for remyelination therapy for treating the demyelinating disease multiple sclerosis (MS). The Wnt effector TCF7l2 was upregulated in MS lesions and had been proposed to inhibit oligodendrocyte differentiation. Recent data suggest the opposite yet underlying mechanisms remain elusive. Here we unravel a previously unappreciate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4af3bdb7-f8fe-51ff-ae05-5382ee15fbd9
DOI
10.1101/2020.09.16.300624
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signalingDOI 10.1101/2020.09.16.300624
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.Semantic proximity
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelinationSemantic proximity
Overexpression of OLIG2 and MYT1L Transcription Factors Enhance the Differentiation Potential of Human Mesenchymal Stem Cells into OligodendrocytesSemantic proximity
Rapid and efficient oligodendrocyte differentiation from human pluripotent stem cells via dual inhibition of BMP and Notch signalingSemantic proximity
Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseasesSemantic proximity
Extrinsic cues unlock cross-germ layer differentiation potential of CNS stem cells during regenerationSemantic proximity
Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiationSemantic proximity
A critical role for miR-184 in the fate determination of oligodendrocytesSemantic proximity
The Notch Signaling Pathway Regulates Differentiation of NG2 Cells into Oligodendrocytes in Demyelinating DiseasesSemantic proximity
Sustained ErbB activation causes demyelination and hypomyelination by driving necroptosis of mature oligodendrocytes and apoptosis of oligodendrocyte precursor cellsSemantic proximity
Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination.Semantic proximity
The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cellsSemantic proximity
Select a neighboring publication to make it the new centre.