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Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation

21 Apr 2006

Abstract excerpt

OBJECTIVE: Glial progenitor cells are abundant in adult human white matter. This study was designed to identify signaling pathways regulating their self-renewal and fate. METHODS: We compared the transcriptional profiles of freshly sorted adult human white matter progenitor cells (WMPCs), purified by A2B5-based immunomagnetic sorting, with those of the white matter from which they derived. RESULTS: We identified...

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Glioma Diagnosis and Treatment
Neurogenesis and neuroplasticity mechanisms
Neuroinflammation and Neurodegeneration Mechanisms

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PMID: 16634042
DOI: 10.1002/ana.20812

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