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Article

Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination

29 Dec 2014

Abstract excerpt

The basic helix-loop-helix transcription factor Olig2 is a key determinant for the specification of neural precursor cells into oligodendrocyte progenitor cells. However, the functional role of Olig2 in oligodendrocyte migration and differentiation remains elusive both during developmental myelination and under demyelinating conditions of the adult central nervous system. To decipher Olig2 functions, we generated...

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PMID: 25564492
DOI: 10.1093/brain/awu375

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