Article
Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.
Scientific reports - 23 Oct 2017
Okada Takuya, Keino-Masu Kazuko, Nagamine Satoshi, Kametani Fuyuki, Ohto Tatsuyuki, Hasegawa Masato, van Kuppevelt Toin H, Kunita Satoshi, Takahashi Satoru, Masu Masayuki
Abstract excerpt
Heparan sulfate (HS) has been implicated in a wide range of cell signaling. Here we report a novel mechanism in which extracellular removal of 6-O-sulfate groups from HS by the endosulfatases, Sulf1 and Sulf2, is essential for axon guidance during development. In Sulf1/2 double knockout (DKO) mice, the corticospinal tract (CST) was dorsally displaced on the midbrain surface. In utero electroporation of Sulf1/2...
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