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Article

Variant scoring tools for deep mutational scanning.

Molecular systems biology - 1 Oct 2025

Çubuk Hasan, Jin Xinyi, Phipson Belinda, Marsh Joseph A, Rubin Alan F

Abstract excerpt

Deep mutational scanning (DMS) can systematically assess the effects of thousands of genetic variants in a single assay, providing insights into protein function, evolution, host-pathogen interactions, and clinical impacts. Accurate scoring of variant effects is crucial, yet the diversity of tools and experimental designs contributes considerable heterogeneity that complicates data analysis. Here, we review and...

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PMID: 40781375
DOI: 10.1038/s44320-025-00137-x
PMCID: PMC12494760

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