Article

Globally defining the effects of mutations in a picornavirus capsid

2020-10-06

Abstract excerpt

<h4>ABSTRACT</h4> The capsids of non-enveloped viruses are highly multimeric and multifunctional protein assemblies that protect the viral genome between infection cycles, dictate host and cell tropism, and mediate evasion of humoral immune responses. As such, capsids play key roles in viral biology and pathogenesis. Despite their importance, a comprehensive understanding of how mutations affect viral fitness acr...

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Literature Corpus work: 5bd00f3d-3335-5c23-b189-ca9da06fd6d9
DOI: 10.1101/2020.10.06.327916

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