Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-by-inhibitor interactions to dissect enterovirus replication.

Nature communications - 11 Apr 2026

Bakhache William, Symonds-Orr Walker, Dolan Patrick T

Abstract excerpt

Replication organelles of positive-sense RNA viruses are essential to virus biology, yet their molecular mechanisms remain poorly defined. While deep mutational scanning (DMS) measures the impact of mutations across viral proteins, it cannot resolve their effects on specific functions. Here, we present a strategy to integrate mutational scanning in the context of specific virus- and host-targeted inhibitors with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Enterovirus
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Viral Nonstructural Proteins

Share to Viral Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 41965907
DOI: 10.1038/s41467-026-71900-3
PMCID: PMC13247092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-by-inhibitor interactions to dissect enterovirus replication.PMID 41965907Read ↗

Comparative analysis of deep mutational scanning datasets in enteroviruses A and B identifies functional divergence and therapeutic targets.Semantic proximity Read ↗

Comparative Analysis of Deep Mutational Scanning Datasets in Enteroviruses A and B Identifies Functional Divergence and Therapeutic TargetsSemantic proximity Read ↗

A Sweep of Earth’s Virome Reveals Host-Guided Viral Protein Structural Mimicry and Points to Determinants of Human DiseaseSemantic proximity Read ↗

Applications of Deep Mutational Scanning in Virology.Semantic proximity Read ↗

Globally defining the effects of mutations in a picornavirus capsidSemantic proximity Read ↗

TMEM41B Is a Pan-flavivirus Host Factor.Semantic proximity Read ↗

Amino acid substitutions in norovirus VP1 dictate cell tropism via an attachment process dependent on membrane mobilitySemantic proximity Read ↗

Scanning the horizon: deep mutational scanning approaches in virology.Semantic proximity Read ↗

Return of the Neurotropic Enteroviruses: Co-Opting Cellular Pathways for InfectionSemantic proximity Read ↗

A sweep of earth’s virome reveals host-guided viral protein structural mimicry; with implications for human diseaseSemantic proximity Read ↗

Different mechanisms for human rhinovirus survival in the presence of deleterious amino acid substitutions at virion protein-protein or RNA-protein interfaces.Semantic proximity Read ↗

A Simplified Positive-Sense-RNA Virus Construction Approach That Enhances Analysis ThroughputSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.