Concepts of RNA virus evolution for the design of better antiviral countermeasures.

Abstract excerpt

This century, global human health has been marked by a seemingly increasing list of outbreaks and epidemics caused by RNA viruses - masters of rapid evolution, host switching and immune escape. With a propensity for mutation, coupled with recombination, reassortment and extensive population interactions, RNA viruses generate remarkable genetic diversity within constrained evolutionary landscapes. Although most...

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