Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights from deep mutational scanning in the context of an emerging pathogen.

Biochemical Society transactions - 29 Oct 2025

Call Melissa J, Call Matthew E, Wu Xinyu

Abstract excerpt

Deep mutational scanning (DMS), a high-throughput method leveraging next-generation sequencing, has been crucial in mapping the functional landscapes of key severe acquired respiratory syndrome-coronavirus 2 (SARS-CoV-2) proteins. By systematically assessing thousands of amino acid changes, DMS provides a framework to understand Angiotensin-converting enzyme 2 (ACE2) binding and immune evasion by the spike...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to COVID-19
Share to ACE2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Mutation

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 40905952
DOI: 10.1042/BST20253033
PMCID: PMC12599253

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights from deep mutational scanning in the context of an emerging pathogen.PMID 40905952Read ↗

Deep mutagenesis in the study of COVID-19: a technical overview for the proteomics community.Semantic proximity Read ↗

Mutation informatics: SARS-CoV-2 receptor-binding domain of the spike protein.Semantic proximity Read ↗

Deep mutational scanning of recent SARS-CoV-2 variants highlights changing amino acid preferences within epistatic hotspot residues.Semantic proximity Read ↗

Deep mutational scanning of recent SARS-CoV-2 variants highlights changing amino acid preferences within epistatic hotspot residuesSemantic proximity Read ↗

Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection systemSemantic proximity Read ↗

High-throughput screening of mutations affecting SARS-CoV-2 spike functions.Semantic proximity Read ↗

Comprehensive Deep Mutational Scanning Reveals the Immune-Escaping Hotspots of SARS-CoV-2 Receptor-Binding Domain Targeting Neutralizing AntibodiesSemantic proximity Read ↗

Amino acids 484 and 494 of SARS-CoV-2 spike are hotspots of immune evasion affecting antibody but not ACE2 bindingSemantic proximity Read ↗

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 cladesSemantic proximity Read ↗

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies.Semantic proximity Read ↗

Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain.Semantic proximity Read ↗

Molecular Aspects of Viral Pathogenesis in Emerging SARS-CoV-2 Variants: Evolving Mechanisms of Infection and Host Response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.