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Mapping mutational fitness effects across the coxsackievirus B3 proteome reveals distinct profiles of mutation tolerability.

PLoS biology - 1 Jul 2024

Álvarez-Rodríguez Beatriz, Velandia-Álvarez Sebastian, Toft Christina, Geller Ron

Abstract excerpt

RNA viruses have notoriously high mutation rates due to error-prone replication by their RNA polymerase. However, natural selection concentrates variability in a few key viral proteins. To test whether this stems from different mutation tolerance profiles among viral proteins, we measured the effect of >40,000 non-synonymous mutations across the full proteome of coxsackievirus B3 as well as >97% of all possible...

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Identifiers

PMID: 39012844
DOI: 10.1371/journal.pbio.3002709
PMCID: PMC11251597

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