Article

Two SID-1-dependent genes sensitive to heritable epigenetic changes can also impact reproduction

2026-06-10

Abstract excerpt

Import of double-stranded RNA (dsRNA) into the germ line can have consequences that last for many generations. However, the role of such transgenerational regulation by extracellular dsRNA is unclear. In the nematode C. elegans , entry of dsRNA into the cytosol requires the transmembrane protein SID-1 and loss of SID-1 for a few generations causes changes in gene expression that can persist for hundreds of genera...

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Literature Corpus work: 5a81ba6e-6a05-55f2-b38e-f452db7807bb
DOI: 10.64898/2026.06.08.730950

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