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Article

The RNAi Inheritance Machinery of Caenorhabditis elegans.

Genetics - 1 Jul 2017

Spracklin George, Fields Brandon, Wan Gang, Becker Diveena, Wallig Ashley, Shukla Aditi, Kennedy Scott

Abstract excerpt

Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen in C. elegans that has identified six factors required for RNAi inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two novel nematode-specific factors that we term here (heritable RNAi defective) HRDE-2 and HRDE-4 The new...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Epigenesis, Genetic
Gene Silencing
Phenotype
RNA, Small Interfering

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28533440
DOI: 10.1534/genetics.116.198812
PMCID: PMC5500139

Genes

SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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