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Article

MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance.

Current biology : CB - 24 Apr 2017

Lev Itamar, Seroussi Uri, Gingold Hila, Bril Roberta, Anava Sarit, Rechavi Oded

Abstract excerpt

In C. elegans, alterations to chromatin produce transgenerational effects, such as inherited increase in lifespan and gradual loss of fertility. Inheritance of histone modifications can be induced by double-stranded RNA-derived heritable small RNAs. Here, we show that the mortal germline phenotype, which is typical of met-2 mutants, defective in H3K9 methylation, depends on HRDE-1, an argonaute that carries small...

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Source

Identifiers

PMID: 28343968
DOI: 10.1016/j.cub.2017.03.008

Genes

MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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