Article

Three linked opposing regulatory variants under selection associate with <i>IVD</i>

2022-12-22

Abstract excerpt

<h4>ABSTRACT</h4> While genome-wide association studies (GWAS) and selection scans identify genomic loci driving human phenotypic diversity, functional validation is required to discover the variant(s) responsible. We dissected the IVD locus, implicated by selection statistics, multiple GWAS, and clinical genetics as important to function and fitness. We combined luciferase assays, CRISPR/Cas9 genome-editing, ma...

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Literature Corpus work: 5a806625-7baa-5655-a202-e44bbe6814af
DOI: 10.1101/2022.12.22.521605

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