Article

An integrated platform to systematically identify causal variants and genes for polygenic human traits

2019-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified over 150,000 links between common genetic variants and human traits or complex diseases. Over 80% of these associations map to polymorphisms in non-coding DNA. Therefore, the challenge is to identify disease-causing variants, the genes they affect, and the cells in which these effects occur. We have developed a platform using ATAC-seq, DNase...

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Literature Corpus work: 3e17a0cb-0ae1-576a-a4b8-bef3529ded73
DOI: 10.1101/813618

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