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Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac development and early indicators of cardiac risk

2024-07-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Methylation changes linked to dilated cardiomyopathy (DCM) affect cardiac gene expression. We investigate DCM mechanisms regulated by CpG methylation using multi-omics and causal analyses in the largest cohort of left ventricular tissues available. <h4>Methods</h4> We mapped DNA methylation at ∼850,000 CpG sites, performed array-based genotyping and RNA sequencing in left-vent...

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Literature Corpus work
c58d7e99-23c5-5d5a-b97d-9654d3e246a6
DOI
10.1101/2024.07.16.24310537
Open publication

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Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac development and early indicators of cardiac riskDOI 10.1101/2024.07.16.24310537
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