Article

Regulation of <i>NTRK2</i> alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity

2025-04-07

Abstract excerpt

<h4>ABSTRACT</h4> BDNF signaling through its receptor TRKB plays a critical role in brain development, neuroplasticity and homeostasis. Alternative splicing of the TRKB gene, NTRK2 , generates either the full-length receptor (TRKB-FL) or a truncated isoform (TRKB-T1) that inhibits BDNF signaling and has been implicated in neurodegenerative diseases, psychiatric disorders and cognitive impairments. Here, we show...

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Literature Corpus work: 5a654c3b-82e8-583f-8c34-20e1d5f8f3bf
DOI: 10.1101/2025.04.07.647526

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