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Article

LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF-β1 in Parkinson's Disease.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Oct 2023

Yao Longping, Lu Fengfei, Koc Sumeyye, Zheng Zijian, Wang Baoyan, Zhang Shizhong, Skutella Thomas, Lu Guohui

Abstract excerpt

The gene mutations of LRRK2, which encodes leucine-rich repeat kinase 2 (LRRK2), are associated with one of the most prevalent monogenic forms of Parkinson's disease (PD). However, the potential effectors of the Gly2019Ser (G2019S) mutation remain unknown. In this study, the authors investigate the effects of LRRK2 G2019S on endoplasmic reticulum (ER) stress in induced pluripotent stem cell (iPSC)-induced...

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Identifiers

PMID: 37672887
DOI: 10.1002/advs.202303711
PMCID: PMC10602550

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