Article

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s Disease.

2023-06-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Neural stem cell (NSC) proliferation and differentiation in the mammalian brain decreases to minimal levels postnatally. Nevertheless, neurogenic niches persist in the adult cortex and hippocampus in rodents, primates and humans, with adult NSC differentiation sharing key regulatory mechanisms with development. Adult neurogenesis impairments have been linked to A...

Identifiers and source

Literature Corpus work: fefe610b-b66d-5955-bd32-01feffd13a9f
DOI: 10.21203/rs.3.rs-3029554/v1

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