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Article

Oncogenic role of a developmentally regulated <i>NTRK2</i> splice variant

2022-01-09

Abstract excerpt

Temporally-regulated alternative splicing choices are vital for proper development yet the wrong splice choice may be detrimental. Here we highlight a novel role for the neurotrophin receptor splice variant TrkB.T1 in neurodevelopment, embryogenesis, transformation, and oncogenesis across multiple tumor types in both humans and mice. TrkB.T1 is the predominant NTRK2 isoform across embryonic organogenesis and forc...

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Identifiers and source

Literature Corpus work
ed51063b-c9a7-5570-a1c0-d27c570fddb6
DOI
10.1101/2022.01.07.475392
Open publication

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Oncogenic role of a developmentally regulated <i>NTRK2</i> splice variantDOI 10.1101/2022.01.07.475392
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