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A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

12 Jun 2020

Abstract excerpt

Independent scientific achievements have led to the discovery of aberrant splicing patterns in oncogenesis, while more recent advances have uncovered novel gene fusions involving neurotrophic tyrosine receptor kinases (NTRKs) in gliomas. The exploration of NTRK splice variants in normal and neoplastic brain provides an intersection of these two rapidly evolving fields. Tropomyosin receptor kinase B (TrkB),...

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PMID: 32532995
DOI: 10.1038/s41467-020-16786-5

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