Article

A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer’s mouse model

2023-09-20

Abstract excerpt

<h4>Introduction</h4> TrkB and TrkC receptor signaling promotes synaptic plasticity and interacts with pathways affected by amyloid-β (Aβ)-toxicity. Upregulating TrkB/C signaling could reduce Alzheimer’s disease (AD)-related degenerative signaling, memory loss, and synaptic dysfunction. <h4>Methods</h4> PTX-BD10-2 (BD10-2), a small molecule TrkB/C receptor partial agonist, was orally administered to aged London/...

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Literature Corpus work: 03b2a426-dacd-59bb-b454-cbcb17318c83
DOI: 10.1101/2023.09.18.558138

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A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer’s mouse modelDOI 10.1101/2023.09.18.558138Read

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