Article

Allostery in STAT3 Variant D170A is Mediated by a Rigid Core

2022-06-16

Abstract excerpt

Signal Transducer and Activator of Transcription 3 (STAT3) plays a crucial role in cancer development and thus is a viable target for cancer treatment. STAT3 functions as a dimer mediated by phosphorylation of the SRC-homology 2 (SH2) domain, a key target for therapeutic drugs. While great efforts have been employed towards the development of compounds that directly target the SH2 domain, no compound has yet been...

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Literature Corpus work: 5a50a3d9-fb62-5448-a840-e8af13b226a4
DOI: 10.1101/2022.06.15.495314

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