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Article

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

8 Nov 2019

Abstract excerpt

Src Homology 2 (SH2) domains arose within metazoan signaling pathways and are involved in protein regulation of multiple pleiotropic cascades. In signal transducer and activator of transcription (STAT) proteins, SH2 domain interactions are critical for molecular activation and nuclear accumulation of phosphorylated STAT dimers to drive transcription. Sequencing analysis of patient samples has revealed the SH2...

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PMID: 31717342
DOI: 10.3390/cancers11111757

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