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Article

Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR.

Biophysical journal - 3 Jul 2018

Koss Hans, Bunney Tom D, Esposito Diego, Martins Marta, Katan Matilda, Driscoll Paul C

Abstract excerpt

Phosphatidylinositol phospholipase Cγ (PLCγ) is an intracellular membrane-associated second-messenger signaling protein activated by tyrosine kinases such as fibroblast growth factor receptor 1. PLCγ contains the regulatory γ-specific array (γSA) comprising a tandem Src homology 2 (SH2) pair, an SH3 domain, and a split pleckstrin homology domain. Binding of an activated growth factor receptor to γSA leads to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29972810
DOI: 10.1016/j.bpj.2018.05.031
PMCID: PMC6035297

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