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Article

Allosteric Communication across STAT3 Domains Associated with STAT3 Function and Disease-Causing Mutation.

Journal of molecular biology - 13 Feb 2016

Namanja Andrew T, Wang Jianghai, Buettner Ralf, Colson Loren, Chen Yuan

Abstract excerpt

STAT3 is a member of STAT (signal transducer and activator of transcription) transcription activators. Aberration in STAT3 activity due to constitutive activation or mutations leads to diseases such as cancer and hyper-immunoglobulin E syndrome (HIES). STAT3 contains several structured domains including the Src homology 2 domain (SH2), linker domain (LD), DNA-binding domain (DBD) and the coiled-coil domain. Here...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Multimerization

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Source

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Identifiers

PMID: 26774853
DOI: 10.1016/j.jmb.2016.01.003
PMCID: PMC4767637

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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