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Article

Structural exploration with AlphaFold2-generated STAT3α structure reveals selective elements in STAT3α-GRIM-19 interactions involved in negative regulation.

Scientific reports - 30 Nov 2021

Mishra Seema, Kumar Santosh, Choudhuri Kesaban Sankar Roy, Longkumer Imliyangla, Koyyada Praveena, Kharsyiemiong Euphinia Tiberius

Abstract excerpt

STAT3, an important transcription factor constitutively activated in cancers, is bound specifically by GRIM-19 and this interaction inhibits STAT3-dependent gene expression. GRIM-19 is therefore, considered as an inhibitor of STAT3 and may be an effective anti-cancer therapeutic target. While STAT3 exists in a dimeric form in the cytoplasm and nucleus, it is mostly present in a monomeric form in the mitochondria....

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Identifiers

PMID: 34848745
DOI: 10.1038/s41598-021-01436-7
PMCID: PMC8633360

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