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Article

Structural and mutational analysis of member-specific STAT functions.

Biochimica et biophysica acta. General subjects - 1 Mar 2022

Erdogan Fettah, Qadree Abdul K, Radu Tudor B, Orlova Anna, de Araujo Elvin D, Israelian Johan, Valent Peter, Mustjoki Satu M, Herling Marco, Moriggl Richard, Gunning Patrick T

Abstract excerpt

BACKGROUND: The STAT family of transcription factors control gene expression in response to signals from various stimulus. They display functions in diseases ranging from autoimmunity and chronic inflammatory disease to cancer and infectious disease. SCOPE OF REVIEW: This work uses an approach informed by structural data to explore how domain-specific structural variations, post-translational modifications, and...

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Identifiers

PMID: 34774983
DOI: 10.1016/j.bbagen.2021.130058

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