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Article

STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs.

Journal of cellular and molecular medicine - 1 Jan 2026

Lee Hye Kyung, Cho Gyuhyeok, Chen Jichun, Schultz Aaron B, Lee Sung-Gwon, Liu Chengyu, Furth Priscilla A, Young Neal S, Kim Jungwook, Villarino Alejandro, Hennighausen Lothar

Abstract excerpt

The conserved aspartic acid residue D661 within the STAT3 SH2 domain is a recurrent mutational hotspot in hematologic malignancies, including T-cell large granular lymphocytic leukaemia, myelodysplastic syndromes and acute lymphoblastic leukaemia. To define the functional consequences of distinct STAT3D661 variants, we integrated computational, structural and in vitro and in vivo genetic approaches. AlphaMissense...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41527523
DOI: 10.1111/jcmm.71015
PMCID: PMC12796846

Genes

STAT3
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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