Article

Conservation and divergence in the allosteric architectures of five human protein kinases

2026-08-07

Abstract excerpt

Protein kinases are central to biological regulation, dysregulated in many diseases, and the targets of a hundred clinically-approved drugs. Structural conservation of kinase active sites makes the development of specific inhibitors challenging. Targeting functional secondary sites can increase specificity, reduce toxicity, overcome resistance mutations, and also activate kinases. However, the functional secondary...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 405aca44-eb15-58d1-a2a2-b41308b0f13a
DOI: 10.64898/2026.08.04.742685

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Conservation and divergence in the allosteric architectures of five human protein kinasesDOI 10.64898/2026.08.04.742685Read

The allosteric landscape of the Src kinase.Semantic proximity Read

Geometry-Constrained Prediction of Catalytically Competent Kinase Domains Across the Human KinomeSemantic proximity Read

Allosteric regulation of kinase activity in living cellsSemantic proximity Read

The Landscape of Atypical and Eukaryotic Protein Kinases.Semantic proximity Read

A structural atlas of kinases inhibited by clinically approved drugs.Semantic proximity Read

Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.Semantic proximity Read

Evolution and Engineering of Allosteric Regulation in Protein KinasesSemantic proximity Read

Functional plasticity and evolutionary adaptation of allosteric regulation.Semantic proximity Read

Hierarchical organization endows the kinase domain with regulatory plasticitySemantic proximity Read

Unveiling the Complexity of cis-Regulation Mechanisms in Kinases: A Comprehensive AnalysisSemantic proximity Read

Unveiling the Complexity of cis-Regulation Mechanisms in Kinases: A Comprehensive Analysis.Semantic proximity Read

Defining the Active Conformation of Typical Protein Kinase Domains from Substrate-Bound PDB Structures Enables Active-State AlphaFold2 Models for All 437 Human Catalytic Protein KinasesSemantic proximity Read