Article

Divergent activation of the RXFP1 relaxin receptor by protein and small molecule agonists

2026-06-11

Abstract excerpt

<h4>Summary</h4> RXFP1 is an unusual G protein-coupled receptor (GPCR) that mediates physiological adaptations to pregnancy and is a therapeutic target due to its benefits in treatment of fibrosis and heart failure. Protein and small-molecule agonists are currently in mid-stage clinical trials. Here, we present three cryo-electron microscopy structures of RXFP1: ligand-free, bound to the native agonist relaxin-2,...

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Literature Corpus work: 5a475dc7-f94e-5f30-8690-c7b6c533e0f2
DOI: 10.64898/2026.06.10.731386

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