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Article

Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1).

The Journal of biological chemistry - 12 Dec 2014

Diepenhorst Natalie A, Petrie Emma J, Chen Catherine Z, Wang Amy, Hossain Mohammed Akhter, Bathgate Ross A D, Gooley Paul R

Abstract excerpt

Relaxin, an emerging pharmaceutical treatment for acute heart failure, activates the relaxin family peptide receptor (RXFP1), which is a class A G-protein-coupled receptor. In addition to the classic transmembrane (TM) domain, RXFP1 possesses a large extracellular domain consisting of 10 leucine-rich repeats and an N-terminal low density lipoprotein class A (LDLa) module. Relaxin-mediated activation of RXFP1...

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Identifiers

PMID: 25352603
DOI: 10.1074/jbc.M114.600882
PMCID: PMC4263891

Genes

RXFP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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