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Article

Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors.

Scientific reports - 23 Jan 2014

Ferrie Ann M, Sun Haiyan, Zaytseva Natalya, Fang Ye

Abstract excerpt

We present subclone sensitive cell phenotypic pharmacology of ligands at the β2-adrenergic receptor (β2-AR) stably expressed in HEK-293 cells. The parental cell line was transfected with green fluorescent protein (GFP)-tagged β2-AR. Four stable subclones were established and used to profile a library of sixty-nine AR ligands. Dynamic mass redistribution (DMR) profiling resulted in a pharmacological activity map...

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Identifiers

PMID: 24451999
DOI: 10.1038/srep03828
PMCID: PMC3899747

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Source receipt: pubmed, retrieved 7 Sept 2026.

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