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Article

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1.

Nature communications - 18 Apr 2016

Sethi Ashish, Bruell Shoni, Patil Nitin, Hossain Mohammed Akhter, Scott Daniel J, Petrie Emma J, Bathgate Ross A D, Gooley Paul R

Abstract excerpt

H2 relaxin activates the relaxin family peptide receptor-1 (RXFP1), a class A G-protein coupled receptor, by a poorly understood mechanism. The ectodomain of RXFP1 comprises an N-terminal LDLa module, essential for activation, tethered to a leucine-rich repeat (LRR) domain by a 32-residue linker. H2 relaxin is hypothesized to bind with high affinity to the LRR domain enabling the LDLa module to bind and activate...

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Source

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Identifiers

PMID: 27088579
DOI: 10.1038/ncomms11344
PMCID: PMC4837482

Genes

RXFP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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