Article

Engineering and characterization of a long half-life relaxin receptor RXFP1 agonist

2022-04-19

Abstract excerpt

Relaxin-2 is a peptide hormone with important roles in human cardiovascular and reproductive biology. Its ability to activate cellular responses such as vasodilation, angiogenesis, and anti-inflammatory and anti-fibrotic effects have led to significant interest in using relaxin-2 as a therapeutic for heart failure and several fibrotic conditions. However, recombinant relaxin-2 has a very short serum half-life, lim...

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Literature Corpus work: 1c2c8629-594f-5307-9674-0f272e183f5a
DOI: 10.1101/2022.04.19.488796

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