Article
Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2011
Figueira A C M, Saidemberg D M, Souza P C T, Martínez L, Scanlan T S, Baxter J D, Skaf M S, Palma M S, Webb P, Polikarpov I
Abstract excerpt
Thyroid hormone receptors (TRs) are ligand-gated transcription factors with critical roles in development and metabolism. Although x-ray structures of TR ligand-binding domains (LBDs) with agonists are available, comparable structures without ligand (apo-TR) or with antagonists are not. It remains important to understand apo-LBD conformation and the way that it rearranges with ligands to develop better TR...
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