Article
Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2023
Renna Stephanie A, Zhao Xuefei, Kunapuli Satya P, Ma Peisong, Holinstat Michael, Boxer Matthew B, Maloney David J, Michael James V, McKenzie Steven E
Abstract excerpt
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is a major concern for all individuals that undergo cardiac bypass surgeries or require prolonged heparin exposure. HIT is a life- and limb-threatening adverse drug reaction with an immune response following the formation of ultra-large immune complexes that drive platelet activation through the receptor FcγRIIA. Thrombotic events remain high following the...
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