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Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

2017-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Molecular mechanisms underpinning the genetic risk for type 2 diabetes (T2D) remain poorly understood, hindering translation into new therapies. Recently, genome-wide studies identified two coding variants in Peptidylglycine Alpha-amidating Monooxygenase ( PAM ) associated with T2D risk and measures of beta cell dysfunction. Here, we demonstrate that both risk alleles impact negatively on over...

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Literature Corpus work
5a0ef4ab-2bcb-53ad-af58-640acdc3b548
DOI
10.1101/158642
Open publication

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Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell FunctionDOI 10.1101/158642
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