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Article

PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice.

Diabetologia - 1 Mar 2020

Chen Yi-Chun, Mains Richard E, Eipper Betty A, Hoffman Brad G, Czyzyk Traci A, Pintar John E, Verchere C Bruce

Abstract excerpt

AIMS/HYPOTHESIS: Peptide hormones are first synthesised as larger, inactive precursors that are converted to their active forms by endopeptidase cleavage and post-translational modifications, such as amidation. Recent, large-scale genome-wide studies have suggested that two coding variants of the amidating enzyme, peptidylglycine α-amidating monooxygenase (PAM), are associated with impaired insulin secretion and...

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Source

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Identifiers

PMID: 31984442
DOI: 10.1007/s00125-019-05060-z
PMCID: PMC7864590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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