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Article

Naturally occurring variants of the dysglycemic peptide pancreastatin: differential potencies for multiple cellular functions and structure-function correlation.

The Journal of biological chemistry - 14 Feb 2014

Allu Prasanna K R, Chirasani Venkat R, Ghosh Dhiman, Mani Anitha, Bera Amal K, Maji Samir K, Senapati Sanjib, Mullasari Ajit S, Mahapatra Nitish R

Abstract excerpt

Pancreastatin (PST), a chromogranin A-derived peptide, is a potent physiological inhibitor of glucose-induced insulin secretion. PST also triggers glycogenolysis in liver and reduces glucose uptake in adipocytes and hepatocytes. Here, we probed for genetic variations in PST sequence and identified two variants within its functionally important carboxyl terminus domain: E287K and G297S. To understand functional...

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Identifiers

PMID: 24338022
DOI: 10.1074/jbc.M113.520916
PMCID: PMC3924307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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