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Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists

2023-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Patients with type 2 diabetes vary in their response to currently available therapeutic agents (including GLP-1 receptor agonists) leading to suboptimal glycemic control and increased risk of complications. We show that human carriers of hypomorphic T2D-risk alleles in the gene encoding peptidyl-glycine alpha-amidating monooxygenase (PAM), as well as Pam- knockout mice, display increased resis...

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Literature Corpus work
a1f2d454-fb9a-5e13-bcf0-148c800c69c6
DOI
10.1101/2023.04.07.23288197
Open publication

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Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor AgonistsDOI 10.1101/2023.04.07.23288197
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