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The link between the ANPEP gene and type 2 diabetes mellitus may be mediated by the disruption of glutathione metabolism and redox homeostasis.

Gene - 30 Jan 2025

Korvyakova Yaroslava, Azarova Iuliia, Klyosova Elena, Postnikova Maria, Makarenko Victor, Bushueva Olga, Solodilova Maria, Polonikov Alexey

Abstract excerpt

Aminopeptidase N (ANPEP), a membrane-associated ectoenzyme, has been identified as a susceptibility gene for type 2 diabetes (T2D) by genome-wide association and transcriptome studies; however, the mechanisms by which this gene contributes to disease pathogenesis remain unclear. The aim of this study was to determine the comprehensive contribution of ANPEP polymorphisms to T2D risk and annotate the underlying...

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Case-Control Studies
Diabetes Mellitus, Type 2
Dipeptidases
Genome-Wide Association Study
Glutathione

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidation-Reduction

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PMID: 39489227
DOI: 10.1016/j.gene.2024.149050

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