Article
Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations.
PloS one - 1 Jan 2013
Lam Vincent Kwok Lim, Ma Ronald Ching Wan, Lee Heung Man, Hu Cheng, Park Kyong Soo, Furuta Hiroto, Wang Ying, Tam Claudia Ha Ting, Sim Xueling, Ng Daniel Peng-Keat, Liu Jianjun, Wong Tien-Yin, Tai E Shyong, Morris Andrew P, Tang Nelson Leung Sang, Woo Jean, Leung Ping Chung, Kong Alice Pik Shan, Ozaki Risa, Jia Wei Ping, Lee Hong Kyu, Nanjo Kishio, Xu Gang, Ng Maggie Chor Yin, So Wing-Yee, Chan Juliana Chung Ngor
Abstract excerpt
Type 2 diabetes (T2D) is a complex disease characterized by beta cell dysfunctions. Islet amyloid polypeptide (IAPP) is highly conserved and co-secreted with insulin with over 40% of autopsy cases of T2D showing islet amyloid formation due to IAPP aggregation. Dysregulation in IAPP processing, stabilization and degradation can cause excessive oligomerization with beta cell toxicity. Previous studies examining...
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