Article

The gene signatures of human alpha cells in types 1 and 2 diabetes indicate disease-specific pathways of alpha cell dysfunction

2022-02-25

Abstract excerpt

Glucagon secretion is perturbed in both type 1 and type 2 diabetes (T1D, T2D) the pathophysiological changes at the level of individual pancreatic alpha cells are still largely obscure. Using recently-curated single-cell RNA data from human donors with either T1D or T2D and appropriate controls, we leveraged alpha cell transcriptomic alterations consistent with both common and discrete pathways. Firstly, altered e...

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Literature Corpus work: 97c84565-eaa5-52fe-a1ff-c6cd8bf8acde
DOI: 10.1101/2022.02.22.481528

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