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Article

A multi-omics Mendelian randomization study reveals PAM as a potential therapeutic target for type 2 diabetes.

Journal of translational medicine - 8 Oct 2025

Yi Ming, Feng Xingrong, Guan Qiuyue, Liu Yin, Liu Yunqiang, Su Zhiguang

Abstract excerpt

BACKGROUND: The progression of type 2 diabetes (T2D) is driven by pancreatic β-cell dysfunction and loss, yet current therapies fail to address this core pathophysiology. METHODS: We implemented an integrative pipeline combining genetic and functional data to prioritize T2D targets. We leveraged genome-wide association study (GWAS) and protein quantitative trait loci (pQTL) summary data to infer causal...

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Topics

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Share to Diabetes Mellitus, Type 2
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Molecular Docking Simulation

Share to Molecular Targeted Therapy

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Source

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Identifiers

PMID: 41063246
DOI: 10.1186/s12967-025-07086-x
PMCID: PMC12506332

Genes

PAM
ENG
GOLM1
GSTA1
HIBCH
HP
PLXND1
PTN
SVEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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