Article

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD

2024-05-14

Abstract excerpt

<title>Abstract</title> <p>Background Cellular senescence is a hallmark of aging and has been implicated in Alzheimer’s disease (AD) pathogenesis. Cholesterol accumulation drives cellular senescence; however, the underlying mechanisms are unclear. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis. ABCA1 expression and its trafficking is altered in APOE4 and AD cellula...

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Literature Corpus work: 59edaf77-d333-5b02-8bac-f582bf59abe7
DOI: 10.21203/rs.3.rs-4373201/v1

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